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HealthRadar Yardstick: How reliably do leading AI models explain laboratory results?

A paired benchmark of Google, OpenAI, and Anthropic models using 15 synthetic laboratory cases, repeated generation, masked assessment, and physician adjudication.

HealthRadar Yardstick graphical abstract: 15 synthetic laboratory cases were interpreted three times by each of three model families, producing 135 reports assessed for clinical quality, failure, repeatability, and safety.
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HealthRadar Yardstick examines how consistently three leading language-model families explain synthetic laboratory results under the same study conditions. The study is research—not a commercial AI-ranking service, a clinical validation of HealthRadar, or a measure of real-world error prevalence.

Manuscript/preprint. This study has not yet undergone journal peer review.

#Study at a glance

  • 15 synthetic laboratory cases
  • 3 LLM families
  • 3 independent generations per model per case
  • 135 reports
  • 7 clinical assessment domains
  • Physician adjudication of 91 triggered reports

#Models evaluated

  • Google Gemini 3.1 Pro Preview
  • OpenAI GPT-5.6 Sol
  • Anthropic Claude Fable 5

#Key findings

#Overall clinical quality

Overall clinical quality differed descriptively. Of 45 reports per model, 9 Google reports (20.0%), 36 OpenAI reports (80.0%), and 23 Anthropic reports (51.1%) were classified as excellent.

Stacked bar chart of overall clinical quality for 45 reports per model. Excellent reports were 9 of 45 for Google, 36 of 45 for OpenAI, and 23 of 45 for Anthropic; the remaining reports were acceptable, deficient, or potentially unsafe.

These descriptive results do not, by themselves, establish comparative safety or effectiveness.

#Material clinical failure

Material clinical failure occurred in 6 of 45 Google reports (13.33%), 4 of 45 OpenAI reports (8.89%), and 6 of 45 Anthropic reports (13.33%).

Forest plot of paired differences in material clinical failure with 95% confidence intervals. Every interval crosses zero: OpenAI minus Google, Anthropic minus Google, and Anthropic minus OpenAI.

The paired 95% confidence intervals for every between-model difference included zero. The study therefore did not establish superiority, equivalence, or noninferiority among the models for material clinical failure.

#Shared safety signal

All nine reports classified as potentially unsafe occurred in the same complex case, Case 20. All three models received that classification in all three repetitions under the prespecified physician standard.

This shared case-level signal must not be interpreted as a 6.7% real-world unsafe rate. The cohort was small, synthetic, and purposively constructed; it was not a prevalence sample.

#Repeatability

Exact agreement across all three repetitions occurred in 7 of 15 Google cases, 11 of 15 OpenAI cases, and 8 of 15 Anthropic cases.

Repeatability alone does not establish safety. All three models were highly repeatable on Case 20 while repeatedly failing the same safety standard.

#LLM-as-judge finding

The study scheduled 405 judge evaluations. Of these, 322 were valid and 83 failed procedurally. Restricting analysis to reports with valid assessments from all three judges excluded every potentially unsafe report.

This is a methodological observation about automated LLM evaluation in this study. It is not proof that LLM judging is unreliable in all settings.

#Case-level material clinical failure

Heatmap showing case-level material clinical failure across the three models and three repetitions. Failures cluster in selected cases, and all nine potentially unsafe reports occur in Case 20.

The heatmap shows why aggregate rates and repeatability should be interpreted alongside case-level patterns. The same clinical challenge can recur across models and repetitions.

#Why HealthRadar conducted Yardstick

HealthRadar is investigating how patient-facing interpretation of laboratory results can be evaluated for clinical prioritization, urgency, uncertainty, communication quality, and reproducibility. Yardstick is a research project and should not be presented as a commercial AI-ranking service or as proof of HealthRadar product effectiveness.

#Limitations

  • The study used synthetic cases.
  • The cohort was a purposive set of 15 cases.
  • Each model generated three repetitions per case.
  • Findings apply to the specific model versions and API configurations studied.
  • Physician adjudication was selective rather than independent physician scoring of every report.
  • The study measured no patient outcomes.
  • The results do not support inference about real-world error prevalence.

#Collaboration

Interested in studying clinical AI evaluation, laboratory-result communication, or governed AI? We welcome conversations with researchers, clinicians, health systems, and other potential collaborators.

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Tags

  • Yardstick
  • Clinical AI evaluation
  • Laboratory results
  • Large language models
  • Synthetic benchmark
  • Physician adjudication

Version archive

VersionDateStatusChange
1.0September 21, 2026Manuscript/preprint · Not peer reviewed · September 2026Initial public manuscript/preprint release.
Research and development only: This material is not medical advice and must not be used for medical decisions.